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In Arabidopsis thaliana , low levels of glutathione synthetase have resulted in increased vulnerability to stressors such as heavy metals, toxic organic chemicals, and oxidative stress

However, in OA, M2 numbers are limited and may shift toward an M1-like phenotype under sustained inflammatory stimuli, reducing their capacity to maintain iron homeostasis ( T lymphocytes in OA frequently assume an activated state

In the inflammatory microenvironment, immune cells are involved in activating mesenchymal stromal cells that determine the extent of cancer progression [18]

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