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In the treatment of inflammatory diseases such as RA, the combination of ART and DEX not only plays a role by inhibiting the HIF-1/NF-B signaling pathway, but also promotes ROS scavenging and macrophage polarization from M1 to M2, which modulates inflammatory responses at multiple levels, providing a new perspective for antioxidant treatment strategies ( It was found that artemisinin and its derivatives counteracted oxidative stress in RA
They speculated that the peptide may have attracted the central and peripheral melanocortin pathways to accomplish this function
doi: 10.1152/physrev.00044.2005 27 MiyataYMatsuoTSagaraYOhbaKOhyamaKSakaiH
Fu XM, Wang P, Zhu BT
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