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Mol Biol Rep 48(9):65396550 Tibullo D, Li Volti G, Giallongo C, Grasso S, Tomassoni D, Anfuso CD, Lupo G, Amenta F, Avola R, Bramanti V (2017) Biochemical and clinical relevance of alpha lipoic acid: antioxidant and anti-inflammatory activity, molecular pathways and therapeutic potential

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These side effects can often be managed by taking the medication with food, taking a drug holiday, switching to an extended-release formulation, or starting with a low dosage and gradually increasing over time (Wexler 2021b)