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For instance, patients with liver disease may experience fatigue, jaundice, or abdominal swellingsymptoms related to hepatic dysfunction rather than the elevated B12 itself

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10.1172/JCI9914 J

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Special techniques of opioid drug delivery Patient-controlled analgesia (PCA) PCA is a system which allows the patient to titrate the dose of opioid to suit their individual analgesic requirements

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But in most patients, the skin continues to improve until 2-4 months after stopping intake

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