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The mechanism of action includes several key effects: Stimulating insulin secretion from the pancreas in a glucose-dependent manner, helping to control blood sugar levels Slowing gastric emptying , which prolongs the feeling of fullness after meals Reducing appetite through effects on brain centres that regulate hunger Decreasing glucagon secretion , which helps prevent excessive glucose production by the liver By targeting these multiple pathways, GLP-1 medications can lead to significant weight loss when combined with lifestyle modifications

Without insurance, for most doses, the cost of a 28-day supply is over $1,300

doi:10.1007/s12178-025-09971-w Villarreal-Espinosa JB, Berreta RS, Pallone L, et al

Tirzepatide is a popular dual GIP/GLP-1 receptor agonist sold by Lilly under the brand names Zepbound and Mounjaro