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Second, the molecular details of how iron overload disrupts communication between pericytes and retinal endothelial cells are poorly understood, and therapeutic strategies aimed at this cooperative vulnerability remain confined to cellular and animal models, with no clinical data on efficacy or safety

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Out of the 36 metabolic pathways that showed significant changes in metabolic activity in response to the GDH2 gene deletion when cells were cultured in MM medium, all except phosphonate and phosphinate metabolism were upregulated (Fig