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Histone deacetylase 3 aberration inhibits Klotho transcription and promotes renal fibrosis

114 Ni II , like Zn II and Mn II , can perform Lewis acid chemistry, exemplified by two hydrolytic enzymes, the dinuclear Ni II enzyme urease (Section 5.1.2) and the mononuclear glyoxylase-I, but also functions as a cofactor in [NiFe]-hydrogenase and Ni-superoxide dismutase, among others, where both the Ni I and Ni III oxidation states must be accessible