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This means that the blood vessels are more likely to dilate rapidly due to the release of acetylcholine, causing the sweating and flushing associated with hot flashes.[ref] A clinical trial of an anticholinergic drug found that it was superior to placebo in reducing hot flashes

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Risk categorization is determined based on the presence of atherosclerotic cardiovascular disease or severe TOD [71] (Table S1 and S2)