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The GLP-1 revolution has transformed weight management, but many users discover that losing 15-20% of body weight comes with unintended consequences, including loss of lean muscle mass that can reach 25-40% of total weight lost

This type of stress damages cellular structures, resulting in the degradation of DNA, proteins, lipids and membranes as indicated by (66, 67)

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Some studies have incorporated a loading regimen with higher initial doses, followed by lower maintenance doses of 1-2mg per week