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Furthermore, IL-22-induced claudin-2 upregulation can drive diarrhea and pathogen clearance [90]

Finally, intrinsic and extrinsic pathways can activate the common effector caspases (e.g., 3 or 7) to trigger apoptosis [77]

220,258,259 While the efficacy of statins in alleviating DPN symptoms remains unclear, 260,261 emerging lipid-lowering therapies showed potential in improving nerve function in DPN models