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Microscopically, physiologic pigmentation is characterized by the presence of increased amounts of melanin within the basal cell layer

Animal-model evidence consistently shows local effects: angiogenesis at the injury site (VEGF upregulation), growth-factor signaling (EGF, FGF), nitric oxide pathway modulation, and accelerated tendon-to-bone interface healing in rat Achilles transection studies

The consequences of these risks could be severe and maybe even life threatening for some

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