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In human trials involving women with photoaged skin, it increased skin density and thickness, decreased laxity, improved firmness and clarity, and reduced fine lines and wrinkle depth [9]

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It is often overexpressed in fibrotic lung disease, allergic airway disease, and in the stroma of several cancers (breast, colon, prostate, etc.), where it supports fibrosis, invasion, and metastasis

Research suggests these therapies may address different physiological mechanismsone targeting appetite signaling and the other supporting muscle protein synthesis