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Current HIV treatments, including integrase strand transfer inhibitors (INSTIs), often lead to metabolic complications such as lipodystrophy, which disrupts adipocyte function and lipid distribution 90

Inconsistent dosing schedules diminish therapeutic effect

While Lexapro is not classified under the Controlled Substances Act (CSA) in the United States, and thus not considered physically addictive, prolonged use can lead to psychological dependence

J Intern Med 286(1):3240 Brydges CR et al (2021) Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature