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T2-weighted imaging showed that the off-center region within the control grafts exhibited liquefaction-equivalent hyperintense signals with recognizable boundaries

105 , 125 , 126 , 127 This polarization is at least partly mediated via cAMP/PKA signalling, a canonical downstream pathway of GLP1R activation that has been implicated in suppressing NFB activity and dampening proinflammatory transcriptional programs