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Thus, the selected starting dose and titration algorithm in the IcoSema phase 3 programme account for the higher maximum concentration of semaglutide in IcoSema and are expected to provide an acceptable gastrointestinal adverse event profile

Consult your doctor prior to starting this medicine

This includes optimizing study designs, managing compliance with regulatory standards like GLPs, and ensuring timely data collection and analysis

Indeed, the same supplementation protocol did not change skeletal muscle TC level in young participants (unpublished), suggesting that muscle TC was not affected also in the present study