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Acute Kidney Injury Initial case reports suggested that GLP-1RA treatment could cause acute kidney injury (AKI) in some patients (114)

These metabolic improvements may be beneficial, though it's important to note that Zepbound does not have an FDA-approved indication for cardiovascular risk reduction

Specifically, 1083 primary outcome events occurred among 624 patients in the finerenone group and 1283 primary outcome events occurred among 719 patients in the placebo group

FDA responded by issuing a statement allowing for continued compounding of that drug, even though it is no longer in shortage, and advising that FDA will continue to allow compounding of all GLP-1s, regardless of whether a particular drug is in shortage, until the shortage is resolved for all GLP-1s