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Chronic high-dose vitamin B intake (generally in gram quantities daily over many months) has been linked to severe sensory neuropathy characterized by numbness, impaired proprioception, and paresthesia in a stocking-glove distribution

67 The reasons for this are not clear, but AIDS patients have a deficit in the enzyme gamma cystathionase, which synthesizes cysteine from the methionine

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Luszczek, Research Specialist at the Research Core Facility at Louisiana State University Health Sciences Center in Shreveport for their expert technical assistance