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X-ray diffraction data were collected at the Diamond light source beamlines i04-1, processed using the xia2 pipeline [68], and the structure was solved by molecular replacement with 3KAL and named Gpa-GSS22-apo

Although bariatric surgery can lead to weight loss of at least 25% and long-term weight maintenance, it is not scalable at the population level, and many people are still afraid to have surgery because of the possibility of complications, [135, 136]

Clinicians should monitor thyroid function tests (TSH, free T4) at: Baseline before starting weight loss injections 6-8 weeks after achieving maintenance dose Every 3-6 months during active weight loss After significant weight stabilization Symptoms of overreplacement (palpitations, anxiety, tremor, heat intolerance) should prompt earlier testing