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10 Division of Clinical Immunology, Fondazione Policlinico Universitario A

Disclosure of interest: Yue Gu: nothing to disclose E-Posters - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.02 - GENETICS, OMICS AND BIOMARKERS P2578 - ESOC25-846 CEREBROVASCULAR REACTIVITY AT TRANSCRANIAL DOPPLER AS A POSSIBLE INDICATOR OF VASCULAR INJURY IN ALZHEIMERS DISEASE: CORRELATIONS BETWEEN BHI AND PLASMATIC BIOMARKERS Maria Rosaria Bagnato 1,2 , Martina Gaia Di Donna 1,2 , Chiara Giuseppina Bonomi 1 , Caterina Motta 1 , Alessandro Martorana 1 , Marina Diomedi 1 1 University of Tor Vergata Rome, Rome, Italy, 2 Stroke Unit Department Hospital F

Cu + catalyzes the formation of OH and 1 O 2 from H 2 O 2 , and is oxidized to yield Cu 2+ , which rapidly depletes intracellular GSH levels and decreases the antioxidant capacity of the cell