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It is also associated with some rare but severe issues that people should consider before starting a medication that contains it

It activates melanocortin receptors MC1R and MC3R, suppressing NF-kappaB nuclear translocation and consequently reducing pro-inflammatory cytokine production including TNF-alpha, IL-6, and IL-1beta

The remaining skin is then tightened and sutured to create a smoother, more toned appearance

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