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But glucagon receptors are also expressed in cardiac tissue, where their activation has two well-documented effects: A positive chronotropic effect increasing heart rate and a positive inotropic effect increasing the force of heart contractions
Another important way semaglutide GLP-1 supports weight loss is by slowing how quickly the stomach empties
Retatrutide users report similar fat intolerance but may also experience issues with very large meals of any composition, likely because the triple receptor activation provides more potent gastric slowing
A meaningful share of weight lost on GLP-1 medications can come from lean mass rather than fat, with reported proportions varying across study populations
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