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Similar content being viewed by others Introduction During most of evolutionary history, caloric scarcity was among the greatest threats to survival, resulting in enormous selection pressure for mechanisms to minimize energy expenditure

Excitingly, researchers are also exploring long-term effects of GLP-1 agonists that extend beyond conventional diabetes treatment

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This may help prevent the long-term deleterious effects of excessive nutritional intake on liver mitochondrial function and insulin sensitivity, thereby preventing the development of metabolic diseases such as fatty liver and NAFLD (269)