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The primary concern is the potential for hypoglycemia

Quantification of IL-6, IL-8, IL-1 and PGE2 by enzyme-linked immunoassay (ELISA) Supernatants obtained from the qPCR assay were centrifuged at 600 g for 6 min and used to estimate concentration using bovine IL-8 ELISA kits (#3114-1A-6, Mabtech, Nacka, Sweden), IL-6 (#ESS0029, Thermo Fisher Scientific), IL-1 (#ESS0027, Thermo Fisher Scientific) and PGE2 (#514010, Cayman Chemicals, Ann Arbor, MI, USA) according to the manufacturer's instructions

At the same time, a subtle but important shift is emerging

MEN 2 encompasses two subtypes: MEN 2A (characterized by MTC, pheochromocytoma, and primary hyperparathyroidism) and MEN 2B (characterized by MTC, pheochromocytoma, marfanoid habitus, and mucosal neuromas)