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Further, in primary mouse hepatocytes isolated from DIO mice, pre-treatment with G49 increased insulin sensitivity manifested by elevations in insulin-induced AKT Ser473 phosphorylation (Fig
Brandt S, Ballhause TM, Bernhardt A, Becker A, Salaru D, Le-Deffge HM, et al
The magnitude of HbA1c reduction was closely correlated with the increase in -cell glucose sensitivity, suggesting that alleviating glucose toxicity would be important for improving -cell glucose sensitivity
The change from baseline to week 68 was a supportive secondary outcome in STEP 8, and the difference between semaglutide and liraglutide was ||||| || |||| ||| ||||| || ||||||| Body Mass Index The mean change from baseline to week 68 in BMI was reported as a supportive secondary outcome in the STEP 1 to STEP 4 studies, and thus was not part of the statistical testing hierarchy
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