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O-GlcNAc serves as a nutrient sensor in the brain, with the cellular identity and the extensive morphology of neurons and glia determining how O-GlcNAc responds to both general and neuron-specific stimuli, as well as the functional consequences of these responses

A combined metabolic analysis and targeted treatment approach such as that suggested by this study has the potential to address the specific biology of a childs neurodevelopmental condition thereby resulting in more effective treatment and better outcomes

Common causes include insufficient dosing, poor dietary choices, medications that promote weight gain, thyroid dysfunction, or simply needing a different approach