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Clinically, there is some evidence from post-hoc analyses in cohorts of low/intermediate-1 risk MDS patients with iron overload that iron chelators as DFX may improve hematological parameters after administration over at least one year in a small proportion of the patients (141145)

The neutralizing antibody against IGF-1 (human IGF-1 antibody, goat IgG) was from R&D Systems, and the anti-IGF-1 mouse monoclonal antibody was from Santa Cruz Biotechnology

It can make symptoms of B12 deficiency look similar, making it hard to diagnose