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Therefore, localized delivery methods, such as intravitreal implants, nanoparticle carriers, or gene therapy aimed at retinal GLP-1R expression, are essential for maximizing therapeutic effectiveness while minimizing systemic exposure

However, this also makes it challenging to distinguish whether GLP-1RAs exert their effects by directly regulating immune cells or indirectly improving metabolic parameters

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Oral replacement can be difficult during periods of vomiting and IV replacement is frequently necessary