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According to one scientific theory, L-carnitine may block the enzyme acidic sphingomyelinase , which prevents sphingomyelin breakdown in cells [53]

Overall, dual agonists are showing efficacy in both weight and cardiovascular risk reduction

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Data on common gastrointestinal side effects of different incretin-based therapies compared to placebo, pooled from other published systematic reviews and meta-analyses, highlights the lowest OR for nausea, vomiting, and diarrhoea with cagrilintide [Table 4].[22,24] Therefore, cagrilintide can be considered a promising therapeutic option for weight loss in obese individuals who may not tolerate GLP1RAs or have a lower tolerance for nausea and vomiting