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These effects make mazdutide especially relevant for individuals with type 2 diabetes or prediabetes associated with obesity

In vitro studies typically use concentrations between 1 nM and 10 M depending on cell type and measured marker

BMC Womens Health

The central dopaminergic system contains dopaminergic neurons localised in the VTA and the substantia nigra, projecting to the NAc, amygdala, hippocampus, prefrontal cortex and dorsal striatum [24]