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The UACR reductions were dose-dependent, larger at higher doses, and sustained through 72 weeks of treatment without any detrimental effect on estimated glomerular filtration rate

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This decrease was more pronounced when adipocytes from HSL-null mice were utilized, a finding that suggests cooperativity exists between the two enzymes, and indeed, a synergistic effect has been observed on lipolysis when cells are cotransfected with both desnutrin/ATGL and HSL (144)

Linus Pauling Institute Oregon State University Updated in December 2004 by: Jane Higdon, Ph.D