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Teeth loosen, bones break more easily, and once-healed breaks may recur

15 , 16 This study synthesizes 21 RCTsincluding the latest CV and renal outcome studiesinvolving nearly 100,000 patients, applies incidence rate ratios (IRRs) to account for variable follow-up, incorporates trial sequential analysis, and provides the most comprehensive pooled evaluation to date of both efficacy and safety in DM and non-DM populations

A new evaluation is more useful than assuming the dose simply needs to be increased

"I have several patients who've been able to lower their LDL a little bit with psyllium, which is a safe, inexpensive product," says Dr