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Similarities and differences Lets explore some of the similarities and differences concerning semaglutide vs tirzepatide as it pertains to weight loss: Both medications work by limiting damaging postprandial glucose excursions (PPGEs) (aka blood sugar spikes) Both medications work by balancing hormone levels which can be disrupted due to lifestyle, diet, and stress Both medications increase adiponectin levels, which facilitates the further breakdown of fatty acids Both medications reduce systemic inflammation The only key difference between the two is that tirzepatide acts on both GIP and GLP-1 (although it binds more strongly to GIP receptors than GLP-1 receptors), whereas semaglutide only acts on GLP-1 receptors

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However, they warned that Ozempic is not yet ready to replace the three medications approved by the Food and Drug Administration for alcohol abuse

doi:10.1016/j.neuroscience.2009.02.037 Holst, J