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Lipid peroxidation, a principal feature of ferroptosis, generates products such as MDA, 4-hydroxyhexenal, and 4-HNE that serve as valuable indicators for assessing the extent of lipid peroxidation and ferroptosis (14, 56)

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Moreover, pharmacokinetic evaluations reveal that AOD 9604 has a short plasma half-life of about three to four minutes intravenously and slower absorption when administered orally