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In MS, greater reserve means that a higher lesion load and more atrophy are required before clinical signs of neurological impairment become apparent 36,37

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Expression of the GHS-R1a mRNA is found in several nuclei of the hypothalamus, hippocampus, substantia nigra, ventral tegmental area (VTA), dorsal and median raphe nuclei, anterior pituitary gland, pancreatic islets, adrenal gland, thyroid, lung, liver, kidney, immune cells, intestine, adipose tissue, and myocardium