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Por otra parte, TZP induce remisin de la esteatohepatitis asociada a disfuncin metablica (MASH) confirmada histolgicamente de forma dosis-dependiente (44-62% de casos, segn dosis) y mejora de al menos un estadio de fibrosis heptica en el 51-55% de los casos, cifras superiores a placebo45 (fig

Substituent effects on the stability and antioxidant activity of spirodiazaselenuranes

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Small molecule GLP-1 agonists in the clinic Orally dosed small molecule receptor agonists of GLP-1R such as danuglipron, lotiglipron and orforglipron (Figure 1) have been discovered and have progressed into clinical trials