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A series of 7 calibrators were prepared in blood spiking ipamorelin at a final concentration of 100, 50, 25, 10, 5, 2, and 1 ng/mL

It undergoes significant first-pass metabolism in the liver and intestines, where the enzyme arginase breaks it down, reducing bioavailability

124 Therefore, strengthening the research on the pharmacokinetics and pharmacodynamics of AMPs, and establishing the analysis of the correlation between in vitro stability and bioavailability in animal models may solve this problem

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