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Another strength is the use of MR analysis, a method able to overcome common sources of bias in observational studies, such as residual confounding and reverse causality
In SELECT, semaglutide 2.4 mg subcutaneously weekly reduced MACE by 20% (HR 0.80, 95% CI 0.720.90) with a 1.5% absolute risk reduction over a mean follow-up of 39.8 months [3]
Keeping these in range helps protect muscle and nerve function and supports daily performance
The data reinforce that GLP-1RAs exert cardiovascular benefit through multiple mechanisms beyond fat reduction, with approximately two-thirds of the effect unexplained by changes in body composition
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