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Using large-scale electronic health records from the Shanghai Hospital Link Database, we investigate incident depressive and anxiety disorders during GLP-1RA treatment and after its discontinuation in people with type 2 diabetes, compared with dipeptidyl peptidase-4 inhibitors (DPP4is) or sodiumglucose cotransporter-2 inhibitors (SGLT2is)

This activation triggers a series of events involving a specific network, relayed via t he hypothalamus, resulting in enhanced insulin secretion due to relief from SNS-mediated inhibition, which elicits metabolic improvement in obese mice

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This study, for the first time, proved cardioprotective effect of GLP-1 in rat hearts and gave the foundation for exploring new theraputical potential of GLP-1 agonists