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Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice

Across the panel of 84 mRNAs screened in the array, eight were induced or repressed two folds or more in the samples of BPC-157 treatment compared with that of controls

In addition, the inhibition of the Xc system, the subsequent accumulation of ROS, and the decrease of GSH levels create a void in the antioxidant defenses of the cell, which may ultimately lead to ferroptosis (Xie et al., 2016)