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Some people require the full 3.0 mg maintenance dose for several weeks before experiencing significant appetite suppression, as the medication is gradually escalated over five weeks from 0.6 mg daily

PMID: 7937345

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Sensitivity analyses using MR-Egger, weighted median, weighted mode, simple mode, maximum likelihood, and RAPS (Supplementary Table S4) showed consistent directionality of effects for schizophrenia, anxiety disorders, and autism