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Sustained use is what trial protocols approximate

Factors affecting the degradation rate of poly(lactide-co-glycolide) microspheres in vivo and in vitro

Progress in Neurobiology, 76 (1), 1-21

Nail melanoma occurs mainly on the first finger of the hand and on the big toe,1,7,8,41 and so a new-onset longitudinal melanonychia in an adult, at either of these sites, is considered suspicious.1,9,14,26,51 The Hutchinson sign, which consists of pigmentation in the proximal nail fold and cuticle, is a classic sign of subungual melanoma.1,9,13,14 However, many other entities can produce nonpathologic pigmentation in the cuticle