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Hypoglycemia (low blood sugar) is primarily a risk for patients taking concurrent insulin or sulfonylureas, as tirzepatide itself has a glucose-dependent mechanism that generally limits hypoglycemia risk when used alone

We have found neurotoxicity and nutritional factors are some of the prime suspects in symptoms such as anxiety and depression

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Peer review Peer review information Nature Communications thanks Nilufer Yuksel and the other anonymous reviewer(s) for their contribution to the peer review of this work