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Guidelines from the American Academy of Pediatrics and the Endocrine Society recommend intensive behavioral weight loss programs as first-line treatment for teen obesity, with pharmacotherapy considered only after documented failure of structured lifestyle modification over 6+ months

1 and 2, Tables 16, video descriptions, methods and instrumentation

Those drugs work by activating one or two of the same receptors

Biochemical characterization of the lasso peptide chlorinase by Luo, Dong, and coworkers identified the chlorinase ChlH to be chlorinating two of the three tryptophan side chains in the RiPP chlorolassin [51]