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A number of commonly used off-label ICP lowering drugs, including acetazolamide and topiramate, have a deleterious effect on cognitive function [12, 20, 21]

Disease-specific alterations in the enteric virome in inflammatory bowel disease

The TRANSCEND-T2D-1 trial adds a second pressure point: 16.8% body weight reduction in patients with type 2 diabetes, a population that consistently underperforms on weight-loss endpoints with existing agents