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In particular, the cardiovascular implications of such high oxalate levels in the circulation are of great concern: in our murine model of dietary oxalate-induced CKD, mice develop a clear presentation of cardiovascular disease including cardiac fibrosis and profound arterial hypertension [108]

28 Growing evidence suggests that zinc functions not only as a neurotransmitter for cell-to-cell communication but also as an intracellular signaling molecule, facilitating the transduction of various signaling cascades in response to extracellular stimuli

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