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A 1,250 calorie daily deficit exceeds what most people can achieve through diet alone without severe restriction

Your body is adapting to dramatically reduced food intake

Ethics statement The animal study was approved by Guilin Medical University Institutional Animal Care and Use Committee

Common Topical Application Patterns Use case Facial anti-aging (community use) Concentration 1-2% Frequency Once or twice daily Cycle length 8-12 weeks Use case Scalp / hair-research interest Concentration 1-3% Frequency Daily Cycle length 12+ weeks ongoing Use case Compounded post-procedure Concentration 1-2% Frequency Per clinician guidance Cycle length Per clinician guidance Topical concentrations are typically expressed as percent weight