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Markers to watch include: Vitamin B12 levels may decrease over time, especially in people with reduced dietary intake or those combining semaglutide with metformin (which independently reduces B12 absorption)

A major study from March 2025 involving 350,000 individuals found that patients taking Ozempic for two years faced more than double the risk of developing NAION compared to those using other type 2 diabetes treatments

Effects on six indices at birth

Ebrahimi-Mameghani, M., et al., The Effect of Alpha-Lipoic Acid on Liver Function and Metabolic Markers in Obese Patients with Non-Alcoholic Fatty Liver Disease: A Double - Blind Randomized Controlled Trial