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The polyethylene glycol (PEG) and polyoxyethylene (100) stearate (PEG-100 stearate) matrix gradually softened, dissolved, and released EGCG-Zn at body temperature, facilitating the maintenance of effective drug concentrations in the rectum [47,48,49,50,51]
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No, the accumulation to steady state is not harmful but rather the intended therapeutic level
The accumulation of dysfunctional mitochondria with abnormal morphology contributes to the progression of kidney diseases (Galvan et al., 2017)
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