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visceral fat fell about 40%. After withdrawal, insulin resistance returned in proportion to regained weight. Maintaining some weight loss did not preserve the full metabolic benefit when substantial regain occurred

Indeed, activation of GLP-1R in different brain regions reduces food intake 6 and we clearly show that the OB is among these brain areas, with the demonstration that GLP-1-driven OB output activity also modulates food intake in a DIO model

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