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Only one study in patients with gastro-esophageal reflux disease (GERD) took the effort of comparing CLE to classical Ussing chamber experiments, which showed no differentiation between GERD and controls by probe-based CLE and no correlation of CLE findings and ex vivo permeability (51)

The Lancet Diabetes & Endocrinology , 10(1), 45-57

Studies on the intestinal microbiota have shown an inverse relationship between microbiota diversity and neurological disorders, a reduction in Bacteroidetes , and reduced expression of TJ proteins in the intestinal mucosa [95, 113,114,115]